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The compound is currently in a Phase 1b clinical trial in combination with Pegasys (peginterferon alfa-2a) and Copegus (ribavirin).
The clinical programme for ITMN-19, under a previous collaboration agreement, is now being transitioned to Roche which, starting in Phase 2, will oversee the complete global development and registration programme. In addition to the USD15m milestone payment, InterMune could potentially receive up to an additional USD435m in milestones, assuming the continued successful development and commercialisation of ITMN-191 in the United States and other countries. Roche funds 67% of the global development costs of ITMN-191 and also has rights to other HCV protease inhibitor development candidates resulting from the research collaboration. The companies will co-commercialise ITMN-191 in the United States and share profits on a 50/50 basis. InterMune will receive royalties outside the United States.
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