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Ceregene Inc reports data from Phase 2 clinical trial of CERE-120 for Parkinson's disease

Thu. November 27, 2008; Posted: 06:54 AM
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Nov 27, 2008 (M2 EQUITYBITES via COMTEX) -- CEGE | Quote | Chart | News | PowerRating -- Ceregene Inc (NASDAQ-NMS:CEGE), a biopharmaceutical company, announced on 26 November its clinical data from a double-blind, controlled Phase 2 trial of CERE-120, which was conducted in 58 patients with advanced Parkinson's disease. The patients were enrolled across nine leading academic medical centres in the US, with two thirds of patients receiving CERE-120 and one third enrolled into a control group.

According to the company, the trial did not demonstrate an appreciable difference between patients treated with CERE-120 versus those in the control group. CERE-120 appeared to be safe and well tolerated.

CERE-120 is composed of an adeno-associated virus (AAV) vector carrying the gene for neurturin (NTN), a naturally occurring protein known to repair damaged and dying dopamine-secreting neurons, keeping them alive and restoring normal function. A Parkinson's disease is a progressive movement disorder and its main symptoms are caused by a reduction in dopamine containing nerve cells of the midbrain. Parkinson's patients exhibit a progressive inability to initiate and control physical movements.

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