Transition Therapeutics completes enrollment in Phase II diabetes trial

Fri. February 06, 2009; Posted: 09:27 AM

Feb 06, 2009 (Datamonitor via COMTEX) -- TTHI | Quote | Chart | News | PowerRating -- Transition Therapeutics has completed patient enrollment for a Phase II clinical study of gastrin analog, TT-223, in patients with type 2 diabetes.

The study is a randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the safety, tolerability and efficacy of daily TT-223 treatments for 12 weeks with a six-month follow-up.

Approximately 80 patients with type 2 diabetes have been enrolled in the study. Patients receive a daily treatment of TT-223 in addition to their current regimen of oral glucose lowering agents (metformin and/or thiazolidinediones).

Transition and Eli Lilly and Company have entered into a licensing and collaboration agreement granting Lilly exclusive worldwide rights to develop and commercialize gastrin-based therapies, including the lead compound TT-223. Gastrin-based therapies are an emerging class of potential disease-modifying therapies for patients with diabetes, and have been shown to provide sustained improvement in glycemic control in preclinical models and early clinical studies.

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