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From January 2005 to February 2009, an aggregate amount of 278923385 shares of CVTX have been shorted for a total dollar value of $4,741,697,545.00. The CVTX SqueezeTrigger price of $17.058 is the volume weighted average price that all shorts are short in shares of CVTX. There is still approximately $214,934,602.40 of potential short covering in shares of CVTX.
SqueezeTrigger.com has built a massive database that collects, analyzes and publishes a proprietary SqueezeTrigger Price for each stock that has been shorted. The data has then been integrated into an automated trading platform which can be used to connect to a live online broker and automate your trading of short squeeze events. It is extremely powerful with lightening fast execution at a very low price. Both the trading software and SqueezeTrigger data feed are available at http://www.squeezetrigger.com.
CV THERAPEUTICS I (NASDAQ:CVTX) CV Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of new small molecule drugs for the treatment of cardiovascular diseases. The Company has two approved cardiovascular products: Ranexa (ranolazine extended-release tablets) and ACEON (perindopril erbumine) Tablets. Ranexa was approved in the United States, in January 2006, for the treatment of chronic angina in patients who have not achieved an adequate response with other antianginal drugs. ACEON, an angiotensin converting enzyme inhibitor (ACE) inhibitor, is approved in the United States, in August 2005, for use in patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction (MI), and for the treatment of patients with essential hypertension. The Company co-promotes ACEON in the United States with its partner Solvay pharmaceuticals, Inc. In addition CV Therapeutics is developing regadenoson, a selective A2A-adenosine receptor agonist, for potential use as a pharmacologic agent in myocardial perfusion imaging (MPI) studies and is in the late-stage clinical development.
Based on the anti-ischemic properties the Company has observed in previous studies of Ranexa, it also is evaluating Ranexa for potential treatment and long-term prevention of acute coronary syndromes in the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary Syndromes (MERLIN TIMI-36) study. This study is being conducted under a special protocol assessment (SPA), agreement with the United States Food and Drug Administration (FDA). The oral doses of Ranexa used in MERLIN TIMI-36 have been studied in previous Phase III clinical trials.
In addition to performing periodic safety assessments, an independent data safety monitoring board (DSMB), overseeing MERLIN TIMI-36 conducted an interim efficacy analysis when approximately half of the anticipated major cardiovascular events occurred. A significant drug treatment effect on the rate of cardiovascular death with a p-value of less than 0.001 was pre-specified as being required for the DSMB to consider a recommendation to stop the study early. In February 2006, the Company was informed that the DSMB recommended that the study continue as planned.
In March 2004, the Company submitted a marketing authorization application, (MAA), under a centralized procedure to European regulatory authorities seeking approval of ranolazine for the treatment of chronic angina in Europe. In October 2005, European regulatory authorities indicated that additional clinical pharmacokinetic data are needed prior to potential approval of ranolazine for the treatment of chronic angina in Europe. Therefore, the Company withdrew the MAA seeking approval of ranolazine in Europe.
In October 2005, the results of the first Phase III trial evaluating the use of regadenoson as a pharmacologic stress agent in MPI studies were presented as a Late Breaking Clinical Trial at the American Society of Nuclear Cardiology Scientific Sessions 2005 in Seattle. The study met its primary endpoint by showing that MPI studies conducted with regadenoson were comparable to MPI studies conducted with Adenoscan. In this study, regadenoson was generally well tolerated, and the most common adverse events reported in patients who received regadenoson were headache, chest pain, shortness of breath, flushing and gastrointestinal discomfort.
This multinational, randomized, double blind pivotal Phase III study of 784 patients undergoing MPI studies was designed to evaluate the comparability of MPI studies conducted with regadenoson and Adenoscan. All study participants received a clinically indicated baseline MPI study using Adenoscan. Participants then were randomized in a double-blind fashion to receive either regadenoson or Adenoscan in a second MPI study. Each patient's scans were classified as indicating normal, moderate or severe ischemia. Baseline and blinded scans were then evaluated to determine if the scans were comparable.
The SqueezeTrigger database of approximately 1 billion short sale transactions goes back to January 1, 2005 and calculates the exact price at which the Total Short Interest is short in each stock. This data was never before available prior to January 1, 2005 because the Self Regulatory Organizations (primary exchanges) guarded it aggressively. After the SEC passed Regulation SHO, exchanges were forced to allow data processors like SqueezeTrigger.com to access the data. Total Short Interest is the number of shares shorted but not yet covered, and is different from total short volume. To access SqueezeTrigger Prices ahead of potential short squeezes beginning, visit http://www.squeezetrigger.com
About SQUEEZETRIGGER.COM
WWW.SQUEEZETRIGGER.COM is a service designed to help bonafide shareholders of publicly traded US companies fight short selling. SqueezeTrigger.com has built a proprietary database that uses Threshold list feeds and short sale time and sale data from NASDAQ, AMEX and NYSE to generate detailed and useful information to combat the short selling problem. For the first time, actual trade by trade data is available to the public that shows the attempted size, actual size, price and average value of short sales in stocks that have been shorted. This information is valuable in determining the precise point at which short sellers go out-of-the-money and start losing on their short trades.
SQUEEZETRIGGER.COM has built a massive database that collects, analyzes and publishes a proprietary SqueezeTrigger for each stock that has been shorted. The SqueezeTrigger database of nearly one billion short sale transactions goes back to January 1, 2005 and calculates the exact price at which the Total Short Interest is short in each stock. This data was never before available prior to January 1, 2005 because the Self Regulatory Organizations (primary exchanges) guarded it aggressively. After the SEC passed Regulation SHO, exchanges were forced to allow data processors like SqueezeTrigger.com to access the data.
The SqueezeTrigger database collects individual short trade data on over 7,000 NYSE, AMEX and NASDAQ stocks and general short trade data on nearly 8,000 OTCBB and PINKSHEET stocks. Each month the database grows by approximately 50,000,000 short sale transactions and provides investors with the knowledge necessary to time when to buy and sell stocks with outstanding short positions. By tracking the size and price of each month's short transactions, SQUEEZETRIGGER.COM provides institutions, traders, analysts, journalists and individual investors the exact price point where short sellers start losing money and a short squeeze can begin.
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