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Pursuant to the agreement, Roche will fund studies of select molecules attached to Raptor's proprietary NeuroTrans. NeuroTrans is Raptor's proprietary receptor-associated protein (RAP)-based technology programme designed to deliver therapeutics across the BBB, with the potential to provide safer, less intrusive and more effective therapies to treat a wide variety of brain disorders.
In addition, the agreement grants Roche with an exclusive worldwide licence to NeuroTrans for use in the delivery of diagnostic and therapeutic molecules across the BBB.
Scientists at Raptor and Roche will actively collaborate on the project. Raptor will receive an initial upfront fee for the collaboration to cover its portion of the initial studies, along with development milestone payments and royalties in exchange for the licensing of NeuroTrans.
According to Raptor, medical research has identified hundreds of potential therapeutic compounds that might be highly effective in treating devastating neurodegenerative diseases. The majority of these compounds do not cross the BBB by themselves. The challenge of finding a means to deliver these compounds to the brain has resulted in an intensive search for "BBB transporter molecules" that could be attached to these potential therapeutics and, following intravenous administration, deliver the drug to the brain.
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