Altus initiates dosing in Phase II growth hormone deficiency trial

Posted on: Thu, 11 Jun 2009 13:13:00 EDT

Symbols: ALTU

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Jun 11, 2009 (Datamonitor via COMTEX) --
ALTU | Quote | Chart | News | PowerRating -- Altus Pharmaceuticals, a biopharmaceutical company has initiated patient dosing in its Phase II trial for ALTU-238 in growth hormone deficiency pediatric subjects.

The Phase II ALTU-238 pediatric trial is being conducted in approximately 18 clinical sites in the US and targets enrolling 36 growth hormone deficient pediatric patients. ALTU-238 has been studied in a series of Phase I and Phase II studies in healthy and growth hormone (GH) deficiency adults.

According to Altus, ALTU-238 is a long-acting, extended-release formulation of recombinant human growth hormone, which is being developed utilizing the company's proprietary protein crystallization technology. ALTU-238 is a ready-to-use liquid suspension of crystallized rhGH that preserves the structure of the rhGH molecule without the need for pegylation, polymerization, or encapsulation and enables administration through a fine gauge needle.

Georges Gemayel, president and CEO of Altus, said: "Moving this pediatric trial forward is an important step in re-establishing the value of the ALTU-238 program and Altus.

"This Phase II pediatric trial is the fifth clinical study to evaluate ALTU-238. Previous ALTU-238 studies have demonstrated pharmacokinetic and pharmacodynamic profiles that are supportive of and consistent with a once-per-week dosing regimen."

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