New ETF Book by Larry Connors - Click here to read more
Orally administered arimoclomol is a molecular chaperone amplifier that is believed to help reduce the accumulation of damaged proteins that may play a role in multiple diseases and disorders, the Company noted in a release.
"These results help explain how arimoclomol achieved the dramatic improvements in functional recovery that we observed in our previously announced rat stroke studies," said CytRx President and CEO Steven A. Kriegsman. "This better understanding of arimoclomol's mechanism of action is an important piece of information that we expect will be valuable in attracting potential pharmaceutical or biotechnology partners for further development of this exciting drug candidate. Currently, t-PA is the only FDA-approved treatment for stroke and must be administered within three hours of the initiation of stroke. We believe that arimoclomol has the potential to reach a much larger market, as our animal studies have shown statistically significant results even when animals are treated ten hours or more after stroke onset. In addition, clinical testing of arimoclomol for stroke recovery could be less expensive, as more patients could be treated at fewer sites due to the expanded therapeutic window."
The study was conducted under the direction of world-renowned stroke expert Dr. Michael Chopp of the Department of Neurology in the Henry Ford Health System, Detroit, Michigan and the Department of Physics, Oakland University, Rochester, Michigan. Detailed cellular analysis in the brains of rats treated with arimoclomol following stroke inducement showed significantly increased molecular chaperone expression, decreases in both the number of cells undergoing programmed cell death (apoptosis) and the number of microglial cells that cause inflammation, and, most importantly, increases in the number of developing neurons sprouting new projections, called neurites, which are indicative of neuroregeneration.
Stroke is the result of oxygen deprivation to regions of the brain through diminished blood flow, usually due to a blood clot. Stroke affects about 700,000 Americans each year. On average, every 40 seconds someone in the United States has a stroke, and stroke is the leading cause of serious, long-term disability, according to the American Heart Association.
"We expected arimoclomol to increase chaperone expression and therefore probably prevent cells from undergoing apoptosis; however, we were elated to discover that it also controlled the proliferation of these inflammatory microglial cells and stimulated neuroregeneration as well," said Jack Barber, Ph.D., CytRx Chief Scientific Officer. "These latter effects may explain arimoclomol's ability to restore brain function even when administered well after the stroke event, because the negative effects of inflammatory cells and the positive effects of neuroregeneration occur much later than the initial damage."
((Comments on this story may be sent to health@closeupmedia.com))
More News:
Market Updates |
Stock Alerts |
All Trading News |
Stock Index
About TradingMarkets | Contact | Advertise | Careers | Link to Us | Site Map | Help | Terms & Conditions | Privacy Policy | Return Policy | Testimonials | Feedback
The Connors Group, Inc. ("Company") is not an investment advisory service, nor a registered investment advisor or broker-dealer and does not purport to tell or suggest which securities or currencies customers should buy or sell for themselves. The analysts and employees or affiliates of Company may hold positions in the stocks, currencies or industries discussed here. You understand and acknowledge that there is a very high degree of risk involved in trading securities and/or currencies. The Company, the authors, the publisher, and all affiliates of Company assume no responsibility or liability for your trading and investment results. Factual statements on the Company's website, or in its publications, are made as of the date stated and are subject to change without notice.
It should not be assumed that the methods, techniques, or indicators presented in these products will be profitable or that they will not result in losses. Past results of any individual trader or trading system published by Company are not indicative of future returns by that trader or system, and are not indicative of future returns which be realized by you. In addition, the indicators, strategies, columns, articles and all other features of Company's products (collectively, the "Information") are provided for informational and educational purposes only and should not be construed as investment advice. Examples presented on Company's website are for educational purposes only. Such set-ups are not solicitations of any order to buy or sell. Accordingly, you should not rely solely on the Information in making any investment. Rather, you should use the Information only as a starting point for doing additional independent research in order to allow you to form your own opinion regarding investments. You should always check with your licensed financial advisor and tax advisor to determine the suitability of any investment.
HYPOTHETICAL OR SIMULATED PERFORMANCE RESULTS HAVE CERTAIN INHERENT LIMITATIONS. UNLIKE AN ACTUAL PERFORMANCE RECORD, SIMULATED RESULTS DO NOT REPRESENT ACTUAL TRADING AND MAY NOT BE IMPACTED BY BROKERAGE AND OTHER SLIPPAGE FEES. ALSO, SINCE THE TRADES HAVE NOT ACTUALLY BEEN EXECUTED, THE RESULTS MAY HAVE UNDER- OR OVER-COMPENSATED FOR THE IMPACT, IF ANY, OF CERTAIN MARKET FACTORS, SUCH AS LACK OF LIQUIDITY. SIMULATED TRADING PROGRAMS IN GENERAL ARE ALSO SUBJECT TO THE FACT THAT THEY ARE DESIGNED WITH THE BENEFIT OF HINDSIGHT. NO REPRESENTATION IS BEING MADE THAT ANY ACCOUNT WILL OR IS LIKELY TO ACHIEVE PROFITS OR LOSSES SIMILAR TO THOSE SHOWN.
The Connors Group, Inc.
10 Exchange Place, Suite 1800
Jersey City, NJ 07302
© Copyright 2009 The Connors Group, Inc.
