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Under the terms of the agreement, Roche will make an upfront cash payment of $12 million and fund PTC's research efforts. Subject to achievement of several successive milestones, there is the potential for PTC to earn up to $239 million in research, development, regulatory and commercial milestone payments per target.
PTC would also receive up to double digit royalties for all products resulting from this collaboration. Roche has the option to add four targets to the collaboration across therapeutic areas, for additional cash payments.
According to PTC Therapeutics, GEMS is the company's novel and proprietary technology platform for the identification of small-molecules that modulate post-transcriptional control mechanisms.
Christer Nordstedt, head of CNS discovery at Roche, said: "We are pleased to enter into this collaboration with PTC Therapeutics. PTC's expertise in small molecules addressing RNA biology and the demonstrated productivity of their GEMS technology platform make this an attractive collaboration.
"We believe that this novel and highly innovative technology will enable Roche to address important disease mechanisms that were intractable with conventional approaches. This may have profound impact on the treatment and management of several central nervous system (CNS) disorders and therefore lead to great benefits for the patient."
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