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Under the terms of the agreement, Astrazenca will assume the responsibility for developing two molecules (NKTR-118 and NKTR-119) from the Indian company's portfolio, including the initiation of clinical studies for one of its molecule, Nektar said in a statement.
Under the agreement Nektar will receive an upfront payment of US$125 million for both compounds and it can get a payment of up to US$235 million on achieving certain regulatory milestones.
Nektar may get payments of up to US$375 million if the product achieves considerable commercial success.
"Nektar will also be eligible to receive significant double-digit royalty payments on sales of NKTR-118 worldwide," the company said.
NKTR-118, is being developed for the treatment of constipation using opium-based pain relieving products and NKTR-119 for treatment of pain without constipation. The agreement is, however, subject to review by the US authorities.
Nektar is headquartered in San Carlos, California and has a research and development facility in India.
(PTI)lm
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