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In March 2009, Synta initiated the first Phase I/II clinical study of STA-9090 in hematologic malignancies with a twice-weekly dosing schedule. This is the fourth clinical study initiated on STA-9090, a synthetic, small molecule Hsp90 inhibitor with a novel chemical structure that is unrelated to the ansamycin class of Hsp90 inhibitors, including 17-AAG. The other ongoing clinical trials are once-a-week and twice-a-week dosing studies in patients with solid tumors.
The open-label Phase I/II study in patients with hematologic malignancies is designed to identify the recommended dose of STA-9090 for further study in patients with hematologic malignancies, based on a once-weekly intravenous dosing schedule, and to characterize its safety and efficacy profile in this patient population.
Jeffrey Lancet, principal investigator on the trial, said: "Based on preclinical data as well as early clinical data from on-going trials, we believe STA-9090 is a highly potent inhibitor of Hsp90 with the potential to be best in its class.
"This clinical trial will allow us to determine the optimal dose for STA-9090, to understand the signaling pathways mediated by Hsp90 inhibition within leukemic cells, and to provide additional insight on its clinical activity in refractory hematologic malignancies."
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