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Keryx Biopharmaceuticals, Inc. (KERX) announced the initiation of a Phase 2 clinical study to evaluate KRX-0401 (perifosine) as a single agent treatment for relapsed or refractory Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL). The study is currently open for enrollment at Duke University, and it is being externally funded.
KRX-0401 (perifosine) is a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway and several other key signal transduction pathways in both hematologic and solid tumor cancers. Keryx is preparing to initiate a Phase 3 trial by year-end, under Special Protocol Assessment (SPA), for patients with advanced multiple myeloma.
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