The objective of the clinical trials in India is to determine the efficacy of low dose oral interferon in reducing the severity of infection with influenza viruses such as H1N1.
Amarillo Biosciences (ABI) has been conducting studies on the use of low-dose interferon to treat and prevent respiratory tract disease in animals and has found it to be a safe, effective oral therapy for cats, cattle, and horses.
In a Phase II clinical trial being conducted in Perth, Western Australia, volunteers are being given ABI's low-dose oral interferon for prevention and treatment of influenza. The study, which is being conducted by researchers at the University of Western Australia and funded by the Health Department of Western Australia, is nearing completion.
This double-blind, placebo-controlled trial is expected to show that ABI's orally administered interferon lozenges can safely reduce both the infection rate and the severity of symptoms in subjects who are exposed to influenza and other respiratory viruses during a typical flu season. The company plans to release the results of this important study before the end of 2009.
Joseph Cummins, president and CEO of ABI, said: "Influenza viruses mutate to evade the effects of anti-viral drugs. Influenza viruses do not mutate to evade interferon, but instead they have a strategy to sabotage the host interferon system. By giving people interferon orally, we believe we can overcome this viral strategy. It is my belief that low-dose oral interferon will be a beneficial therapy of all influenza viruses, not just the H1N1 strain."
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