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One of the awards can be extended to three years with a potential $2.5 million additional funding, if certain goals and milestones are met.
The first award is a Phase I grant for the development of a hematopoietic tumor-targeting humanized antibody conjugated site-specifically with four interferon-a2b groups. This recombinant immunocytokine was created using the patented Dock-and-Lock method developed by scientists at Immunomedics and its majority-owned subsidiary, IBC Pharmaceuticals.
The National Institutes of Health (NIH) has also awarded the company a multi-year Phase II grant for the development of F-18 labeled peptides for pretargeted positron-emission tomography, or PET, imaging of pancreatic cancer.
The company recently reported a new proprietary method of labeling peptides with F-18 for improved PET imaging. Two US patents have been issued on this labeling method.
Another multi-year Phase II grant was awarded to support a clinical trial of combined radio- and immunotherapy of aggressive non-Hodgkin's lymphoma. Combining veltuzumab with yttrium-90-labeled epratuzumab was found to improve treatment responses in a human lymphoma model, and now will be tested in patients.
Cynthia Sullivan, president and CEO of Immunomedics, said: "We are pleased to receive these grants from the NIH and we are proud that NIH peer review has recognized the potential of our new technologies for improved approaches to cancer imaging and therapy."
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