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According to Isis, the study showed consistent and statistically significant reductions in multiple short and intermediate measures of glucose control. In addition to lowering blood glucose, ISIS 113715 caused statistically significant and clinically meaningful reductions in low-density lipoprotein cholesterol (LDL-C). Consistent with the preclinical data with ISIS 113715, a tendency toward weight loss was observed even in this short-term study without strict dietary control. The effect of ISIS 113715 on weight was preceded by a statistically significant increase in circulating adiponectin, a hormone that is increased with weight loss. ISIS 113715 demonstrated a favorable safety profile with no exacerbation of sulfonylurea-induced hypoglycemia or other clinically significant adverse effects, the company said. The analysis demonstrated statistically significant reductions in multiple indices of glucose control as compared to placebo in patients with type 2 diabetes on stable doses of sulfonylurea. The measures of glucose control evaluated were - fasting serum glucose, a spot measure of glucose control; weekly self-monitored blood glucose (SMBG), a one-week average of daily fasting glucose measurements; fructosamine, a measure of glucose over the preceding two to four weeks; and glycated albumin, a measure of average glucose over the preceding four weeks. In the 200mg/week cohort, there was a 25mg/dl decrease in averaged weekly fasting SMBG (p=0.026 versus placebo) and a 25umol/l decrease in serum fructosamine (p=0.009 versus placebo). Further, glycated albumin was also statistically significantly reduced and similar results were observed for fasting blood glucose. ISIS 113715 was well tolerated, the company added. http://www.datamonitor.com Republication or redistribution, including by framing or similar means, is expressly prohibited without prior written consent. Datamonitor shall not be liable for errors or delays in the content, or for any actions taken in reliance thereon For full details on Isis Pharmaceuticals Inc (ISIS) click here. Isis Pharmaceuticals Inc (ISIS) has Short Term PowerRatings of 4. Details on Isis Pharmaceuticals Inc (ISIS) Short Term PowerRatings is available at This Link.
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