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The grant will support a global health research project conducted by Rajan George, the chief technology officer of Paladin Biosciences, titled 'dendritic cell receptor-targeted malaria vaccines'.
To receive funding, Dr George showed in a two-page application how his idea falls outside current scientific paradigms and might lead to significant advances in global health.
Paladin Biosciences will use its proprietary Chimigen platform technology to produce a malaria vaccine that targets the parasite at various stages of the infection, and test the vaccine in the laboratory for immunogenicity.
The Chimigen platform technology is a dendritic cell receptor-targeted approach to produce highly immunogenic vaccine that induces both antibody and cell-mediated immune responses without the need for an adjuvant, the company said.
Dr George said: "We are honored to be selected for this Grand Challenges Explorations grant, and we look forward to applying our novel Chimigen platform technology to the development of a malaria vaccine that may one day make a real impact on global health. The Chimigen platform technology is currently being used by Paladin Biosciences to develop therapeutic agents for hepatitis B and C, alphavirus and influenza virus infections."
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