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LXRX: Management Comments on Positive Phase 2 Results for LX1031 in IBS

Posted on: Mon, 16 Nov 2009 13:57:00 EST

Symbols: LXRX

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Ridgeland, MS, NOV 16, 2009 (EventX/Knobias.com via COMTEX) --
LXRX | Quote | Chart | News | PowerRating -- By Fain Hughes, fhughes@knobias.com

Lexicon Pharmaceuticals, Inc. (LXRX) announced last week that its investigational new drug, LX1031, a tryptophan hydroxylase (TPH) inhibitor, demonstrated positive results in clinically important parameters for the treatment of non-constipating irritable bowel syndrome (IBS). Top-line results showed that treatment with one gram of LX1031 four times daily produced a statistically significant improvement in global assessment of relief of IBS pain and discomfort over the four-week dosing period as compared to placebo (p=0.0465). Improvements in global assessment parameters also corresponded with statistically significant improvements in stool consistency.

The study included 155 patients with either diarrhea-predominant IBS or mixed IBS. Two dose levels were evaluated: a 250 mg dose and a 1,000 mg dose, each administered four times daily (QID). LX1031 was well tolerated, with no statistically significant differences in adverse events observed between placebo and either treatment group.

Dr. Arthur T. Sands, President and CEO of Lexicon, commented in a conference call, "We find these top line results exciting and very encouraging. We believe these results further validate our genetic strategy to discover breakthrough treatments for human disease, which is the mission of our company."

He added, "It is important to note that these results are preliminary, and we expect to have the final study report in Q1 of 2010."

Dr. Brian Zambrowicz, Chief Scientific Officer at Lexicon, noted, "We believe that the overall safety and efficacy data support further development of this novel mechanism to treat IBS, and these results validate our therapeutic strategy."

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For full details on Lexicon Pharmaceuticals Inc (LXRX) LXRX. Lexicon Pharmaceuticals Inc (LXRX) has Short Term PowerRatings at TradingMarkets. Details on Lexicon Pharmaceuticals Inc (LXRX) Short Term PowerRatings is available at This Link.

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