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Takeda initiates Phase II reflux esophagitis trials

Posted on: Thu, 19 Nov 2009 09:52:00 EST

Symbols: TKPHF

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Nov 19, 2009 (Datamonitor via COMTEX) --
TKPHF | Quote | Chart | News | PowerRating -- Takeda Pharmaceutical Company has reported that TAK-438, which is the drug for acid-related diseases, has entered into Phase II clinical trials for the treatment of patients with reflux esophagitis in Japan.

According to Takeda, TAK-438, originated by the company, is a potassium-competitive acid blocker that suppresses gastric acid secretion by inhibiting the binding of potassium ion (K+) to H+,K+-ATPase; it is a completely different mechanism of action from conventional proton pump inhibitors (PPIs).

Nancy Joseph-Ridge, general manager of pharmaceutical development division at Takeda, said: "We expect TAK-438 to have greater acid suppression which may provide better clinical efficacy than PPIs which are widely used to treat acid-related diseases. We will continue the development of TAK-438 so that we might be able to offer it to patients as an optimal treatment option for the acid-related diseases, including reflux esophagitis, as quickly as possible."

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