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Addex's ADX48621 shows positive primate Parkinson's data

Posted on: Tue, 24 Nov 2009 04:17:00 EST

Symbols: ADDXF

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Nov 24, 2009 (M2 EQUITYBITES via COMTEX) --
ADDXF | Quote | Chart | News | PowerRating -- Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN)
(Zurich: ADXN) announced today that its ADX48621 showed positive data
for non-human Parkinson's disease.

ADX48621 is a metabotropic glutamate receptor 5 (mGluR5) negative
allosteric modulator (NAM) that has completed Phase I testing and is
scheduled to start Phase IIa testing in Parkinson's disease next year.

The company said that in a non-human primate model of Parkinson's
disease (PD) levodopa induced dyskinesia (LID), ADX48621 statistically
and significantly inhibited LID.

More specifically, the compound inhibited dose dependently both chorea
and dystonia, the two major components of LID, without affecting the
beneficial effects of levodopa.

There is currently no approved treatment available for PD-LID.

Addex had reported earlier this year that when tested in a rat model,
oral administration of ADX48621 dose-dependently reversed the catalepsy
induced by haloperidol in three independent experiments.

The company said that these data indicate that ADX48621 has potential
as a treatment for Parkinsonian symptoms as well as LID symptoms.

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