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Ipsen initiates Phase II endometrial cancer trial

Posted on: Fri, 27 Nov 2009 05:03:00 EST

Symbols: IPSNY

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Nov 27, 2009 (Datamonitor via COMTEX) --
IPSNY | Quote | Chart | News | PowerRating -- French pharmaceutical company Ipsen has initiated an international, multicenter, controlled, randomized Phase II clinical trial to evaluate the safety and efficacy of BN83495, its investigational steroid sulfatase inhibitor, in advanced endometrial cancer.

BN83495 is currently being studied in several clinical studies in patients with hormone-dependent cancers.

The clinical trial will compare single-agent BN83495 to megestrol acetate in post-menopausal women with histologically confirmed hormone receptor positive endometrial cancer, presenting with recurrent or advanced disease not eligible for treatment with surgery and radiotherapy.

The primary endpoint for the study is progression-free survival. Overall survival and response rate will be evaluated as secondary endpoints. This is the first Phase II clinical trial to begin in 2009 examining the safety and efficacy of BN83495 in patients with different solid tumors.

Stephane Thiroloix, executive vice president of corporate development, said: "We are very pleased to be moving BN83495 into Phase II in this indication. This steroid sulfatase inhibitor can potentially significantly improve lives of patients with advanced endometrial cancer. With further indications in breast, prostate and ovarian cancers, we believe Ipsen with its focus on hormone-dependent cancers will fully leverage the value of BN83495."

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