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From January 2005 to September 2008, an aggregate amount of 38724685 shares of SGMO have been shorted for a total dollar value of $271,072,795.00. The SGMO SqueezeTrigger price of $7.173 is the volume weighted average price that all shorts are short in shares of SGMO. There is still approximately $67,152,564.00 of potential short covering in shares of SGMO.
SqueezeTrigger.com has built a massive database that collects, analyzes and publishes a proprietary SqueezeTrigger Price for each stock that has been shorted. The data has then been integrated into an automated trading platform which can be used to connect to a live online broker and automate your trading of short squeeze events. It is extremely powerful with lightening fast execution at a very low price. Both the trading software and SqueezeTrigger data feed are available at http://www.squeezetrigger.com .
Sangamo BioSciences Inc. - Common Stock (NASDAQ:SGMO) Sangamo BioSciences, Inc. (Sangamo), incorporated on June 22, 1995, is engaged in the research, development and commercialization of deoxyribonucleic acid (DNA)-binding proteins for the therapeutic regulation and modification of disease-related genes. The Company's technology platform is based on the engineering of a naturally occurring class of proteins referred to as zinc finger DNA-binding proteins (ZFPs). Sangamo uses engineered ZFPs to make ZFP transcription factors (ZFP TFs), which are proteins that bind to DNA and are able to turn genes on or off. In addition, ZFPs may be engineered to create zinc finger nucleases (ZFNs). Engineered ZFNs can be used to cut genomic DNA at a pre-selected sequence location, facilitating either ZFN-mediated correction of genes that contain disease-causing mutations, or disruption of genes that facilitate or are responsible for disease pathology.
The Company's ZFP technology platform potentially constitutes a new therapeutic approach enabling the regulation or modification of therapeutically generated gene targets that have proven intractable to conventional methods of drug discovery. By developing ZFP Therapeutic products based on regulation or modification of such targets at the DNA level, Sangamo is focused on establishing a new therapeutic product development technology platform for a new class of drugs. In November 2005, the Company completed the enrollment and treatment of the first Phase I clinical trial of a ZFP Therapeutic (SB-509) in patients with diabetic neuropathy (DN). One of Sangamo's corporate partners, Edwards Lifesciences (Edwards), has also initiated two Phase I clinical studies to evaluate the safety and preliminary efficacy of a Sangamo ZFP Therapeutic, EW-A-401, for the treatment of peripheral artery disease (PAD). In addition, the Company has initiated pre-clinical animal studies of ZFP Therapeutics in congestive heart failure, nerve regeneration, age-related macular degeneration and neuropathic pain. Sangamo has research-stage programs in human immunodeficiency virus (HIV), X-linked severe combined immunodeficiency (X-linked SCID), hemophilia and hemoglobinopathies, cancer and cancer immunotherapy.
ZFP TF (SB-509)
Diabetic peripheral sensory and motor neuropathy is one of the most frequent complications of diabetes. VEGF-A has been demonstrated to have direct neuroproliferative, neuroregenerative and neuroprotective properties. Administration of recombinant VEGF-A or the complementary deoxyribonucleic acid (cDNA) encoding VEGF-A has been observed to retard or partially reverse the condition in preclinical animal models of diabetic neuropathy. Sangamo has completed pre-clinical studies of VEGF-A activation in similar pre-clinical models to confirm and extend these findings by using its ZFP Therapeutic SB-509, designed to up-regulate the endogenous VEGF-A gene. In January 2005, the Company filed an investigational new drug (IND) application with the United States food and Drug Administration for SB-509, indicated for the treatment of mild to moderate DN. As of December 31, 2005, Sangamo had completed enrollment and treatment of a Phase I, single blind, dose-escalation trial to measure the laboratory and clinical safety of SB-509.
ZFP TF (EW-A-401)
PAD is the result of inadequate arterial blood flow to the lower extremities. The Company's PAD program, which comprises the development of a formulation of a ZFP TF (EW-A-401), an activator of VEGF-A for therapeutic angiogenesis, is funded and managed by its partner, Edwards. Edwards filed an IND application in February 2004, and initiated a Phase I clinical trial at the National Heart Lung and Blood Institute (NHLBI) at the National Institutes of Health in August 2004, for EW-A-401 to treat intermittent claudication. In June 2005, Edwards announced that they had also initiated a Phase I human clinical trial for EW-A-401 for critical limb ischemia, the more severe form of PAD, at Duke University Medical Center.
The SqueezeTrigger database of approximately 1 billion short sale transactions goes back to January 1, 2005 and calculates the exact price at which the Total Short Interest is short in each stock. This data was never before available prior to January 1, 2005 because the Self Regulatory Organizations (primary exchanges) guarded it aggressively. After the SEC passed Regulation SHO, exchanges were forced to allow data processors like SqueezeTrigger.com to access the data. Total Short Interest is the number of shares shorted but not yet covered, and is different from total short volume. To access SqueezeTrigger Prices ahead of potential short squeezes beginning, visit http://www.squeezetrigger.com
About SQUEEZETRIGGER.COM
WWW.SQUEEZETRIGGER.COM is a service designed to help bonafide shareholders of publicly traded US companies fight short selling. SqueezeTrigger.com has built a proprietary database that uses Threshold list feeds and short sale time and sale data from NASDAQ, AMEX and NYSE to generate detailed and useful information to combat the short selling problem. For the first time, actual trade by trade data is available to the public that shows the attempted size, actual size, price and average value of short sales in stocks that have been shorted. This information is valuable in determining the precise point at which short sellers go out-of-the-money and start losing on their short trades.
SQUEEZETRIGGER.COM has built a massive database that collects, analyzes and publishes a proprietary SqueezeTrigger for each stock that has been shorted. The SqueezeTrigger database of nearly one billion short sale transactions goes back to January 1, 2005 and calculates the exact price at which the Total Short Interest is short in each stock. This data was never before available prior to January 1, 2005 because the Self Regulatory Organizations (primary exchanges) guarded it aggressively. After the SEC passed Regulation SHO, exchanges were forced to allow data processors like SqueezeTrigger.com to access the data.
The SqueezeTrigger database collects individual short trade data on over 7,000 NYSE, AMEX and NASDAQ stocks and general short trade data on nearly 8,000 OTCBB and PINKSHEET stocks. Each month the database grows by approximately 50,000,000 short sale transactions and provides investors with the knowledge necessary to time when to buy and sell stocks with outstanding short positions. By tracking the size and price of each month's short transactions, SQUEEZETRIGGER.COM provides institutions, traders, analysts, journalists and individual investors the exact price point where short sellers start losing money and a short squeeze can begin.
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